The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences

被引：23

作者：

Brostjan, C

Sobanov, Y

Glienke, J

Hayer, S

Lehrach, H

Francis, F

Hofer, E

机构：

[1] Univ Vienna, Vienna Int Res Cooperat Ctr, Erhard Hofer Dept Vasc Biol & Thrombosis Res, A-1235 Vienna, Austria

[2] Univ Vienna, Vienna Gen Hosp 8G905, Dept Surg, Vienna, Austria

[3] Univ Vienna, Vienna Int Res Cooperat Ctr, Dept Vasc Biol & Thrombosis Res, A-1235 Vienna, Austria

[4] Max Planck Inst Mol Genet, D-14195 Berlin, Germany

来源：

GENES AND IMMUNITY | 2000年 / 1卷 / 08期

关键词：

natural killer cell receptors; NKG2; genes; promoter sequences; transcriptional regulation;

D O I：

10.1038/sj.gene.6363715

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The NKG2 receptor family is crucially involved in target cell recognition by natural killer cells and comprises several activating as well as inhibitory family members. We have established approximately 3 kilobases of upstream promoter sequences of the human NKG2-C, -E and -F genes and have carried out a comparative analysis with available NKG2-A sequences. We found extended regions of homology which contain numerous putative transcription factor binding sites conserved in the NKG2 genes. However, variation in Alu insertion among family members has led to promoter structures unique to the respective family members, which could contribute to differences in transcriptional initiation as well as gene-specific regulation.

引用

页码：504 / 508

页数：5

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