Chromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kong

被引：11

作者：

Chan, ASK

Lam, WK

Wong, MP

Fu, KH

Lee, J

Yew, WW

Chiu, SW

Lung, ML

机构：

[1] HONG KONG UNIV SCI & TECHNOL,DEPT BIOL,KOWLOON,HONG KONG

[2] UNIV HONG KONG,QUEEN MARY HOSP,DEPT MED,POKFULAM,HONG KONG

[3] GRANTHAM HOSP,PATHOL UNIT,ABERDEEN,HONG KONG

[4] GRANTHAM HOSP,TB & CHEST UNIT,ABERDEEN,HONG KONG

[5] GRANTHAM HOSP,CARDIOTHORAC SURG UNIT,ABERDEEN,HONG KONG

[6] UNIV HONG KONG,QUEEN MARY HOSP,DEPT PATHOL,POKFULAM,HONG KONG

来源：

LUNG CANCER | 1996年 / 15卷 / 01期

关键词：

chromosome; genetic alterations; NSCLC;

D O I：

10.1016/0169-5002(96)00570-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We examined 60 non-small-cell lung cancer (NSCLC) patients for evidence of genetic alterations on chromosome 11 with nine polymorphic markers by Southern blot and microsatellite marker analysis. These analyses detected genetic alterations at both the 11p and 11q arms. At the 11p15 Ha-ras locus, the loss of heterozygosity (LOH) occurred in three out of 11 (27.3%) of the informative cases; at the 11p11-q12 D11S149 locus, the LOH occurred in two out of nine (22.2%) of the informative cases; and at the 11q13 INT-2 locus, the LOH occurred in four out of 18 (22.2%) of the informative cases. Microsatellite markers in the 11q12-q13 region revealed genetic alterations for PYGM in eight out of 54 (14.8%) of the specimens studied and 10 out of 55 (18.2%) of the specimens for the INT-2 marker. The data suggest genetic alterations occur in some of the lung cancer patients in both the 11p and 11q regions.

引用

页码：51 / 65

页数：15

共 27 条

[1] 3 TUMOR-SUPPRESSOR REGIONS ON CHROMOSOME-11P IDENTIFIED BY HIGH-RESOLUTION DELETION MAPPING IN HUMAN NON-SMALL-CELL LUNG-CANCER [J].