Z-DNA: the long road to biological function

被引：410

作者：

Rich, A

Zhang, SG

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

[2] MIT, Ctr Biomed Engn, Cambridge, MA 02139 USA

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 07期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1038/nrg1115

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Biologists were puzzled by the discovery of left-handed Z-DNA because it seemed unnecessary. Z-DNA was stabilized by the negative supercoiling generated by transcription, which indicated a transient localized conformational change. Few laboratories worked on the biology of Z-DNA. However, the discovery that certain classes of proteins bound to Z-DNA with high affinity and great specificity indicated a biological role. The most recent data show that some of these proteins participate in the pathology of poxviruses.

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页码：566 / 572

页数：7

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