20(s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/Akt and XIAP pathways

被引：67

作者：

Wang, Jia-He ^{[1
]}

Nao, Jian-Fei ^{[2
]}

Zhang, Meng ^{[1
]}

He, Ping ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Geriatr, Shenyang 110004, Peoples R China

[2] China Med Univ, Shengjing Hosp, Dept Neurol, Shenyang 110004, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Ginsenoside Rg3; HO-8910; Apoptosis; Caspase; LINKED INHIBITOR; PROTEIN; ACTIVATION; EMBELIN; RG(3);

D O I：

10.1007/s13277-014-2497-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Ovarian cancer is a serious tumor which represents a great threat to women's health. Recently, researchers had found that 20(s)-ginsenoside Rg3 could inhibit growth of several cancer cell lines; however, the mechanism is not fully understood so far. In the present study, we found that 20(s)-ginsenoside Rg3 reduced cell viability and induced apoptosis in a dose-and time-dependent manner in the human ovarian cancer cells HO-8910. The induction of apoptosis was accompanied by downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt family proteins and inhibitor of apoptosis protein (IAP) family proteins. 20(s)-ginsenoside Rg3 treatment resulted in activation of caspase-3 and -9, which may partly explain the anti-cancer activity of 20(s)-ginsenoside Rg3. Taken together, our study for the first time suggests that 20(s)-ginsenoside Rg3 is able to enhance apoptosis of HO-8910 cells, at least in part, through downregulation of PI3K/Akt and IAP family proteins. Moreover, the triggering of caspase-3 and -9 activation mediated apoptotic induction. Our data indicate that 20(s)-ginsenoside Rg3 is an effective apoptosis-inducing natural compound in ovarian cancer cells and may have a role in future therapies for ovarian cancer.

引用

页码：11985 / 11994

页数：10

共 37 条

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