Genetic diversity of hepatocellular carcinomas and its potential impact on targeted therapies

被引:33
作者
Zucnan-Rossi, Jessica
Laurent-Puig, Pieme [1 ]
机构
[1] INSERM, U674, F-75010 Paris, France
[2] Univ Paris 07, F-75010 Paris, France
[3] INSERM, UMR S775, F-75006 Paris, France
[4] Univ Paris 05, F-75006 Paris, France
关键词
AKT; Axin; 1; chromosome instability; CTNNB1; gene mutation; HBV; hepatocellular carcinoma; targeted therapy; TP53; transcriptome;
D O I
10.2217/14622416.8.8.997
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Hepatocellular carcinoma (HCC) is one of the most frequent solid tumors worldwide and represents the third cause of mortality among deaths from cancer. It has been extensively studied in terms of genetic alteration in the last 10 years and our knowledge has dramatically increased in this field, leading to the definition of different altered pathways in hepatocarcinogenesis. Recently, a comprehensive study of genetic and transcriptomic alterations in a large series of HCC tumors enabled the identification of a six-group molecular-based classification of HCC, defined by a simple 16-gene signature. This classification is closely related to specific alteration of WNT and AKT oncogenic pathways. Together with the analysis of defined oncogenic proteins, such global classifications could be useful in the prediction of future-targeted therapy efficiency.
引用
收藏
页码:997 / 1003
页数:7
相关论文
共 45 条
[1]   Phase II study of sorafenib in patients with advanced hepatocellular carcinoma [J].
Abou-Alfa, Ghassan K. ;
Schwartz, Lawrence ;
Ricci, Sergio ;
Amadori, Dino ;
Santoro, Armando ;
Figer, Arie ;
De Greve, Jacques ;
Douillard, Jean-Yves ;
Lathia, Chetan ;
Schwartz, Brian ;
Taylor, Ian ;
Moscovici, Marius ;
Saltz, Leonard B. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (26) :4293-4300
[2]   Molecular cloning of a rat chromosome putative recombinogenic sequence homologous to the hepatitis B virus encapsidation signal [J].
Aoki, H ;
Kajino, K ;
Arakawa, Y ;
Hino, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) :7300-7304
[3]   A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma [J].
Bekaii-Saab, Tanios ;
Williams, Nita ;
Plass, Christoph ;
Calero, Miguel Villalona ;
Eng, Charis .
BMC CANCER, 2006, 6 (1)
[4]   Specific association between alcohol intake, high grade of differentiation and 4q34-q35 deletions in hepatocellular carcinomas identified by high resolution allelotyping [J].
Bluteau, O ;
Beaudoin, JC ;
Pasturaud, P ;
Belghiti, J ;
Franco, D ;
Bioulac-Sage, P ;
Laurent-Puig, P ;
Zucman-Rossi, J .
ONCOGENE, 2002, 21 (08) :1225-1232
[5]   Bi-allelic inactivation of TCF1 in hepatic adenomas [J].
Bluteau, O ;
Jeannot, E ;
Bioulac-Sage, P ;
Marqués, JM ;
Blanc, JF ;
Bui, H ;
Beaudoin, JC ;
Franco, D ;
Balabaud, C ;
Laurent-Puig, P ;
Zucman-Rossi, J .
NATURE GENETICS, 2002, 32 (02) :312-315
[6]   Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets [J].
Boyault, Sandrine ;
Rickman, David S. ;
de Reynies, Aurelien ;
Balabaud, Charles ;
Rebouissou, Sandra ;
Jeannot, Emmanuelle ;
Herault, Aurelie ;
Saric, Jean ;
Belghiti, Jacques ;
Franco, Dominique ;
Bioulac-Sage, Paulette ;
Laurent-Puig, Pierre ;
Zucman-Rossi, Jessica .
HEPATOLOGY, 2007, 45 (01) :42-52
[7]   SELECTIVE G-MUTATION TO T-MUTATION OF P53 GENE IN HEPATOCELLULAR-CARCINOMA FROM SOUTHERN AFRICA [J].
BRESSAC, B ;
KEW, M ;
WANDS, J ;
OZTURK, M .
NATURE, 1991, 350 (6317) :429-431
[8]   M6P/IGF2R GENE IS MUTATED IN HUMAN HEPATOCELLULAR CARCINOMAS WITH LOSS OF HETEROZYGOSITY [J].
DESOUZA, AT ;
HANKINS, GR ;
WASHINGTON, MK ;
ORTON, TC ;
JIRTLE, RL .
NATURE GENETICS, 1995, 11 (04) :447-449
[9]   Southern Europe as an example of interaction between various environmental factors: a systematic review of the epidemiologic evidence [J].
Donato, F. ;
Gelatti, U. ;
Limina, R. M. ;
Fattovich, G. .
ONCOGENE, 2006, 25 (27) :3756-3770
[10]   TUMORS OF THE LIVER - PATHOLOGIC FEATURES [J].
EDMONDSON, HA ;
PETERS, RL .
SEMINARS IN ROENTGENOLOGY, 1983, 18 (02) :75-83