The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3

被引：205

作者：

Soto, H

Wang, W

Strieter, RM

Copeland, NG

Gilbert, DJ

Jenkins, NA

Hedrick, J

Zlotnik, A ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular & Mol Biol, Palo Alto, CA 94304 USA

[2] Univ Michigan, Med Ctr, Dept Internal Med, Ann Arbor, MI 48109 USA

[3] NCI, Mammalian Genet Lab, Adv BioSci Labs,Basic Res Program, Frederick Canc Res & Dev Ctr, Ft Detrick, MD 21702 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 14期

关键词：

D O I：

10.1073/pnas.95.14.8205

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel of chemokines for their ability to induce a calcium flux in mouse CXCR3-transfected cells and identified a new ligand for this receptor, the recently reported CC chemokine 6Ckine. This represents an example of a CC chemokine, which binds to a CXC chemokine receptor. Like other ligands of this receptor, 6Ckine has angiostatic properties. 6Ckine is known to chemoattract T cells, In line with this, CXCR3 is expressed preferentially in Th1 cells and in lymphoid organs of the IL-10(-/-) mouse that develops chronic colitis. Its ability to attract T cells as well as its angiostatic properties suggest that 6Ckine may be an effective anti-tumor agent.

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页码：8205 / 8210

页数：6

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