Cardiovascular hybrid drugs: Combination of more than one pharmacological property in one single molecule

被引：76

作者：

Christiaans, JAM ^{[1
]}

Timmerman, H ^{[1
]}

机构：

[1] FREE UNIV AMSTERDAM,DEPT PHARMACOCHEM,DIV MED CHEM,LEIDEN AMSTERDAM CTR DRUG RES,1081 HV AMSTERDAM,NETHERLANDS

来源：

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0928-0987(95)00029-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

[No abstract available]

引用

页码：1 / 22

页数：22

共 64 条

[1] LONG-ACTING DIHYDROPYRIDINE CALCIUM-ANTAGONISTS .5. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR A SERIES OF 2-[[(N-SUBSTITUTED-HETEROCYCLYL)ETHOXY]METHYL]-1,4-DIHYDROPYRIDINE CALCIUM-ANTAGONISTS [J].

ALKER, D ;

CAMPBELL, SF ;

CROSS, PE ;

BURGES, RA ;

CARTER, AJ ;

GARDINER, DG .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (06) :1805-1811

[2]

ALLEN G, 1986, J HYPERTENS, V4, pS131

[3]

AMSCHLER H, 1987, CHEM ABSTR 176183H, V106

[4] DESIGN OF AN ANTITHROMBOTIC ANTIHYPERTENSIVE AGENT (WY-27569) - SYNTHESIS AND EVALUATION OF A SERIES OF 2-HETEROARYL-SUBSTITUTED DIHYDROPYRIDINES [J].

ARCHIBALD, JL ;

BRADLEY, G ;

OPALKO, A ;

WARD, TJ ;

WHITE, JC ;

ENNIS, C ;

SHEPPERSON, NB .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) :646-652

[5] STEREOCHEMICAL IMPLICATIONS OF HYBRID AND PSEUDO-HYBRID DRUGS .3. [J].

ARIENS, EJ .

MEDICINAL RESEARCH REVIEWS, 1988, 8 (02) :309-320

[6]

ARIENS EJ, 1971, DRUG DESIGN, V1

[7] LONG-ACTING DIHYDROPYRIDINE CALCIUM-ANTAGONISTS .1. 2-ALKOXYMETHYL DERIVATIVES INCORPORATING BASIC SUBSTITUENTS [J].

ARROWSMITH, JE ;

CAMPBELL, SF ;

CROSS, PE ;

STUBBS, JK ;

BURGES, RA ;

GARDINER, DG ;

BLACKBURN, KJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (09) :1696-1702

[8] APPROACHES TO VASODILATING-BETA-ADRENERGIC BLOCKING-AGENTS - EXAMPLES OF THE DIHYDROLUTIDINE TYPE [J].

BALDWIN, JJ ;

HIRSCHMANN, R ;

ENGELHARDT, EL ;

PONTICELLO, GS ;

SWEET, CS ;

SCRIABINE, A .

JOURNAL OF MEDICINAL CHEMISTRY, 1981, 24 (05) :628-631

[9] (+)-NIGULDIPINE BINDS WITH VERY HIGH-AFFINITY TO CA-2+ CHANNELS AND TO A SUBTYPE OF ALPHA-1-ADRENOCEPTORS [J].

BOER, R ;

GRASSEGGER, A ;

SCHUDT, C ;

GLOSSMANN, H .

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, 1989, 172 (02) :131-145

[10] THE ALPHA-ADRENOCEPTOR AND BETA-ADRENOCEPTOR BLOCKING POTENCIES OF LABETALOL AND ITS INDIVIDUAL STEREOISOMERS IN ANESTHETIZED DOGS AND IN ISOLATED-TISSUES [J].

BRITTAIN, RT ;

DREW, GM ;

LEVY, GP .

BRITISH JOURNAL OF PHARMACOLOGY, 1982, 77 (01) :105-114

← 1 2 3 4 5 6 7 →