Human COL9A1 and COL9A2 genes.: Two genes of 90 and 15 kb code for similar polypeptides of the same collagen molecule

被引：40

作者：

Pihlajamaa, T

Vuoristo, MM

Annunen, S

Perälä, M

Prockop, DJ

Ala-Kokko, L

机构：

[1] Univ Oulu, Dept Med Biochem, FIN-90220 Oulu, Finland

[2] Univ Oulu, Bioctr, Collagen Res Unit, FIN-90220 Oulu, Finland

[3] Univ Turku, Dept Med Biochem & Mol Biol, Turku, Finland

[4] Allegheny Univ Hlth Sci, MCP Hahnemann Sch Med, Ctr Gene Therapy, Philadelphia, PA 19102 USA

来源：

MATRIX BIOLOGY | 1998年 / 17卷 / 03期

关键词：

cartilage; collagen;

D O I：

10.1016/S0945-053X(98)90063-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we report the complete structure for the human COL9A1 and the complete sequence for the human COL9A2 genes. The COL9A1 gene is about 90 kb and consists of 38 exons. The COL9A2 gene is only about 15 kb, and it contains 32 exons. Sequence analysis of the promoter regions for the human COL9A2, the mouse Col9a2 and the human COL2A1 genes identified a conserved 14 bp sequence. The data also indicated that the alternative exon 1* found in intron 6 of the COL9A1 gene is separated from exon 7 only by a short in tron in the chick, human, mouse and rat genes probably explaining why transcripts from exon 1* are spliced directly to exon 8.

引用

页码：237 / 241

页数：5

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