Magnetic resonance biomarkers of neuroprotective effects in infants with hypoxic ischemic encephalopathy

被引：52

作者：

Azzopardi, Denis ^{[1
]}

Edwards, A. David

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Inst Clin Sci, London, England

来源：

SEMINARS IN FETAL & NEONATAL MEDICINE | 2010年 / 15卷 / 05期

基金：

英国工程与自然科学研究理事会;

关键词：

Biological marker; Diffusion tensor imaging; Diffusion-weighted imaging; Magnetic resonance imaging; Magnetic resonance spectroscopy; Surrogate endpoint; CEREBRAL ENERGY FAILURE; PROTON MR SPECTROSCOPY; APPARENT DIFFUSION-COEFFICIENT; MILD SYSTEMIC HYPOTHERMIA; WHOLE-BODY HYPOTHERMIA; PERINATAL BRAIN-INJURY; NEONATAL ENCEPHALOPATHY; TERM INFANTS; BIRTH ASPHYXIA; NEWBORN PIGLET;

D O I：

10.1016/j.siny.2010.03.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Evaluation of infants with hypoxic ischemic encephalopathy by magnetic resonance spectroscopy and imaging is useful to direct clinical care, and may assist the evaluation of candidate neuroprotective therapies. Cerebral metabolites measured by magnetic resonance spectroscopy, and visual analysis of magnetic resonance images during the first 30 days after birth accurately predict later neurological outcome and are valid biomarkers of the key physiological processes underlying brain injury in neonatal hypoxic ischemic encephalopathy. Visual assessment of magnetic resonance images may also be a suitable surrogate outcome in studies of neuroprotective therapies but current magnetic resonance methods are relatively inefficient for use in early phase, first in human infant studies of novel neuroprotective therapies. However, diffusion tensor imaging and analysis of fractional anisotropy with tract-based spatial statistics promises to be a highly efficient biomarker and surrogate outcome for rapid preliminary evaluation of promising therapies for neonatal hypoxic ischemic injury. Standardisation of scanning protocols and data analysis between different scanners is essential. (c) 2010 Elsevier Ltd. All rights reserved.

引用

页码：261 / 269

页数：9

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