Lewis and secretor gene effects on Lewis antigen and postnatal development of Lewis blood type

被引：11

作者：

Ameno, S

Kimura, H

Ameno, K

Zhang, X

Kinoshita, H

Kubota, T

Ijiri, I

机构：

[1] Kagawa Med Univ, Fac Med, Dept Forens Med, Kita Ku, Kagawa, Japan

[2] Juntendo Univ, Sch Med, Dept Forens Med, Tokyo 113, Japan

[3] Japan Sci & Technol Corp, CREST, Tokyo, Japan

来源：

BIOLOGY OF THE NEONATE | 2001年 / 79卷 / 02期

关键词：

Lewis blood type; postnatal development; Lewis antigen level; Lewis gene; secretor gene; cord blood; infant blood;

D O I：

10.1159/000047073

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Lewis (Le) and Secretor (Se) gene effects on postnatal change in Lewis antigens are described based on the quantitative analysis of Lewis antigens in blood. Genuine Lewis blood types were determined by Le and Se genotyping in DNA samples obtained from umbilical cord blood and infant blood. Lewis(a) (Le(a)) and Lewis(b) (Le(b)) antigen levels were measured by a time-resolved fluoroimmunoassay. We found that Lewis phenotypes in infants over 9 months of age agreed with the genuine types. In cord blood, the dosage effect of the Se gene on antigen levels was observed, but the Le gene effect was not observed. Both Se and Le gene effects were observed in newborn babies' blood 3-6 days after birth. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：91 / 96

页数：6

共 32 条

[1] Lewis genotyping by the PCR-RFLP method in a Japanese population and its evaluation in forensic analysis [J].