Influence of the initiator system, cerium-polysaccharide, on the surface properties of poly(isobutylcyanoacrylate) nanoparticles

被引：25

作者：

Bertholon-Rajot, I ^{[1
]}

Labarre, D ^{[1
]}

Vauthier, C ^{[1
]}

机构：

[1] Fac Pharm Chatenay Malabry, UMR 8612, Lab Physicochim Biopharm Pharmacotech, F-92296 Chatenay Malabry, France

来源：

POLYMER | 2005年 / 46卷 / 04期

关键词：

alkylcyanoacry late; polysaccharide; nanoparticle;

D O I：

10.1016/j.polymer.2004.11.067

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Isobutylcyanoacrylate has been used to form nanoparticles in presence of polysaccharides by two methods of polymerization. To have a better understanding of the relation between the structure of the resulting copolymer and the surface properties of the nanoparticles, the redox radical emulsion polymerization (RREP) was investigated and compared to anionic emulsion polymerization developed by Couvreur et al. (AEP Couvreur). The kinetic study showed that at pH1 the nanoparticles were formed in 5 min by RREP against 30 min in anionic emulsion polymerization (AEP pH1). The diameter of the nanoparticles was mainly affected by the concentrations of cerium and dextran and by the molecular weight of the dextran. The zeta potential was controlled by the characteristics of the polysaccharides (molecular weight and charge). The different methods of polymerization of isobutylcyanoacrylate led to nanoparticles with different surface properties. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1407 / 1415

页数：9

共 23 条

[1] STEALTH ME.PEG-PLA NANOPARTICLES AVOID UPTAKE BY THE MONONUCLEAR PHAGOCYTES SYSTEM [J].