Multistress regulation in Escherichia coli:: Expression of osmB involves two independent promoters responding either to σS or to the RcsCDB his-asp phosphorelay

被引：37

作者：

Boulanger, A ^{[1
]}

Francez-Charlot, A ^{[1
]}

Conter, A ^{[1
]}

Castanié-Cornet, MP ^{[1
]}

Cam, K ^{[1
]}

Gutierrez, C ^{[1
]}

机构：

[1] Univ Toulouse 3, CNRS, Lab Microbiol & Genet Mol, UMR 5100, F-31062 Toulouse, France

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 09期

关键词：

D O I：

10.1128/JB.187.9.3282-3286.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Transcription of the Escherichia coli osmB gene is induced by several stress conditions. osmB is expressed from two promoters, osmBp1 and osmBp2. The downstream promoter, osmBp2, is induced after osmotic shock or upon entry into stationary phase in a sigma(s)-dependent manner. The upstream promoter, osmBp1, is independent of sigma(s) and is activated by RcsB, the response regulator of the His-Asp phosphorelay signal transduction system RcsCDB. RcsB is responsible for the induction of osmBp1 following treatment with chlorpromazine. Activation of osmBp1 by RcsB requires a sequence upstream of its -35 element similar to the RcsB binding site consensus, suggesting a direct regulatory role. osmB appears as another example of a multistress-responsive gene whose transcription involves both a sigma(s)-dependent promoter and a second one independent of sigma(s) but controlled by stress-specific transcription factors.

引用

页码：3282 / 3286

页数：5

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