Vive la difference!

被引:14
作者
Lee, C
机构
[1] Brigham & Womens Hosp, Dept Pathol, Div Cytogenet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
关键词
D O I
10.1038/ng0705-660
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Until very recently, it was widely touted that the complete DNA sequences of any two human beings were 99.9% identical. A new study refutes this notion through a comprehensive comparison of two individual genomes which detects hundreds of new structural genomic variants.
引用
收藏
页码:660 / 661
页数:3
相关论文
共 12 条
[1]   Recent segmental duplications in the human genome [J].
Bailey, JA ;
Gu, ZP ;
Clark, RA ;
Reinert, K ;
Samonte, RV ;
Schwartz, S ;
Adams, MD ;
Myers, EW ;
Li, PW ;
Eichler, EE .
SCIENCE, 2002, 297 (5583) :1003-1007
[2]   Genome-wide detection of segmental duplications and potential assembly errors in the human genome sequence [J].
Cheung, J ;
Estivill, X ;
Khaja, R ;
MacDonald, JR ;
Lau, K ;
Tsui, LC ;
Scherer, SW .
GENOME BIOLOGY, 2003, 4 (04)
[3]  
DELACHAPELLE A, 1974, AM J HUM GENET, V26, P746
[4]   Complex SNP-related sequence variation in segmental genome duplications [J].
Fredman, D ;
White, SJ ;
Potter, S ;
Eichler, EE ;
Den Dunnen, JT ;
Brookes, AJ .
NATURE GENETICS, 2004, 36 (08) :861-866
[5]   The influence of CCL3L1 gene-containing segmental duplications on HIV-1/AIDS susceptibility [J].
Gonzalez, E ;
Kulkarni, H ;
Bolivar, H ;
Mangano, A ;
Sanchez, R ;
Catano, G ;
Nibbs, RJ ;
Freedman, BI ;
Quinones, MP ;
Bamshad, MJ ;
Murthy, KK ;
Rovin, BH ;
Bradley, W ;
Clark, RA ;
Anderson, SA ;
O'Connell, RJ ;
Agan, BK ;
Ahuja, SS ;
Bologna, R ;
Sen, L ;
Dolan, MJ ;
Ahuja, SK .
SCIENCE, 2005, 307 (5714) :1434-1440
[6]   Detection of large-scale variation in the human genome [J].
Iafrate, AJ ;
Feuk, L ;
Rivera, MN ;
Listewnik, ML ;
Donahoe, PK ;
Qi, Y ;
Scherer, SW ;
Lee, C .
NATURE GENETICS, 2004, 36 (09) :949-951
[7]   Genetic analysis of genome-wide variation in human gene expression [J].
Morley, M ;
Molony, CM ;
Weber, TM ;
Devlin, JL ;
Ewens, KG ;
Spielman, RS ;
Cheung, VG .
NATURE, 2004, 430 (7001) :743-747
[8]   A 1.5 million-base pair inversion polymorphism in families with Williams-Beuren syndrome [J].
Osborne, LR ;
Li, M ;
Pober, B ;
Chitayat, D ;
Bodurtha, J ;
Mandel, A ;
Costa, T ;
Grebe, T ;
Cox, S ;
Tsui, LC ;
Scherer, SW .
NATURE GENETICS, 2001, 29 (03) :321-325
[9]   Large-scale copy number polymorphism in the human genome [J].
Sebat, J ;
Lakshmi, B ;
Troge, J ;
Alexander, J ;
Young, J ;
Lundin, P ;
Måner, S ;
Massa, H ;
Walker, M ;
Chi, MY ;
Navin, N ;
Lucito, R ;
Healy, J ;
Hicks, J ;
Ye, K ;
Reiner, A ;
Gilliam, TC ;
Trask, B ;
Patterson, N ;
Zetterberg, A ;
Wigler, M .
SCIENCE, 2004, 305 (5683) :525-528
[10]   A common inversion under selection in Europeans [J].
Stefansson, H ;
Helgason, A ;
Thorleifsson, G ;
Steinthorsdottir, V ;
Masson, G ;
Barnard, J ;
Baker, A ;
Jonasdottir, A ;
Ingason, A ;
Gudnadottir, VG ;
Desnica, N ;
Hicks, A ;
Gylfason, A ;
Gudbjartsson, DF ;
Jonsdottir, GM ;
Sainz, J ;
Agnarsson, K ;
Birgisdottir, B ;
Ghosh, S ;
Olafsdottir, A ;
Cazier, JB ;
Kristjansson, K ;
Frigge, ML ;
Thorgeirsson, TE ;
Gulcher, JR ;
Kong, A ;
Stefansson, K .
NATURE GENETICS, 2005, 37 (02) :129-137