A Sorcerer's apprentice and the rule of five: from rule-of-thumb to commandment and beyond

被引：40

作者：

Abad-Zapatero, Cele ^{[1
]}

机构：

[1] Univ Illinois, Ctr Pharmaceut Biotechnol, Chicago, IL 60680 USA

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 23-24期

关键词：

D O I：

10.1016/j.drudis.2007.10.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：995 / 997

页数：3

共 8 条

[1] Rediscovering the sweet spot in drug discovery [J].

Brown, D ;

Superti-Furga, G .

DRUG DISCOVERY TODAY, 2003, 8 (23) :1067-1077

[2] A rule of three for fragment-based lead discovery? [J].

Congreve, M ;

Carr, R ;

Murray, C ;

Jhoti, H .

DRUG DISCOVERY TODAY, 2003, 8 (19) :876-877

[3]

Gould S. J., 1985, RULE 5 FLAMINGO SMIL, P199

[4]

HAJDUK P, 2007, DRUG DISCOV, V6, P211

[5] Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings [J].

Lipinski, CA ;

Lombardo, F ;

Dominy, BW ;

Feeney, PJ .

ADVANCED DRUG DELIVERY REVIEWS, 1997, 23 (1-3) :3-25

[6] Drug-like properties and the causes of poor solubility and poor permeability [J].

Lipinski, CA .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2000, 44 (01) :235-249

[7]

Taleb N. N., 2007, BLACK SWAN IMPACT HI, V2

[8] Molecular properties that influence the oral bioavailability of drug candidates [J].

Veber, DF ;

Johnson, SR ;

Cheng, HY ;

Smith, BR ;

Ward, KW ;

Kopple, KD .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (12) :2615-2623

← 1 →