Retinal ganglion cell dendritic development and its control - Filling the gaps

被引:16
作者
Wingate, RJT
机构
[1] Department of Developmental Neurobiology, UMDS, Guy's Hospital, London, SE1 9RT, London Bridge
关键词
dendritic competition; inner plexiform layer; neurogenesis; TTX; NMDA; APV; APB; lucifer yellow;
D O I
10.1007/BF02740650
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and ''dendritic competition'' are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling.
引用
收藏
页码:133 / 144
页数:12
相关论文
共 96 条
[1]  
ALTSHULER D, 1992, DEVELOPMENT, V114, P947
[2]  
ALTSHULER DM, 1991, P RET RES F, V3, P37
[3]   SELECTIVE DEPLETION OF BETA-CELLS AFFECTS THE DEVELOPMENT OF ALPHA CELLS IN CAT RETINA [J].
AULT, SJ ;
THOMPSON, KG ;
ZHOU, YF ;
LEVENTHAL, AG .
VISUAL NEUROSCIENCE, 1993, 10 (02) :237-245
[4]   EFFECT OF BILATERAL TECTUM LESIONS ON RETINAL GANGLION-CELL MORPHOLOGY IN RATS [J].
BAHR, M ;
WIZENMANN, A ;
THANOS, S .
JOURNAL OF COMPARATIVE NEUROLOGY, 1992, 320 (03) :370-380
[5]   DENDRITES SHED THEIR DULL IMAGE [J].
BARINAGA, M .
SCIENCE, 1995, 268 (5208) :200-201
[6]   RETROGRADE MODULATION OF DENDRITIC GEOMETRY IN THE VERTEBRATE BRAIN DURING DEVELOPMENT [J].
BLASER, PF ;
CATSICAS, S ;
CLARKE, PGH .
DEVELOPMENTAL BRAIN RESEARCH, 1990, 57 (01) :139-142
[7]   STRATIFICATION OF ON AND OFF GANGLION-CELL DENDRITES DEPENDS ON GLUTAMATE-MEDIATED AFFERENT ACTIVITY IN THE DEVELOPING RETINA [J].
BODNARENKO, SR ;
CHALUPA, LM .
NATURE, 1993, 364 (6433) :144-146
[8]  
BODNARENKO SR, 1995, J NEUROSCI, V15, P7037
[9]  
CAJAL SRY, 1973, VERTEBRATE RETINA, P781
[10]   DEVELOPMENT OF SYNAPSES IN VISUAL SYSTEM OF CAT [J].
CRAGG, BG .
JOURNAL OF COMPARATIVE NEUROLOGY, 1975, 160 (02) :147-166