Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

被引:11
作者
Fodor, Daniela [1 ]
Bondor, Cosmina [2 ]
Albu, Adriana [1 ]
Muntean, Laura [3 ]
Simon, Siao-pin [3 ]
Poanta, Laura [1 ]
Craciun, Alexandra [4 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Internal Med Clin 2, Cluj Napoca 400006, Romania
[2] Iuliu Hatieganu Univ Med & Pharm, Dept Med Informat & Biostat, Cluj Napoca 400006, Romania
[3] Iuliu Hatieganu Univ Med & Pharm, Rheumatol Clin, Cluj Napoca 400006, Romania
[4] Iuliu Hatieganu Univ Med & Pharm, Dept Biochem, Cluj Napoca 400006, Romania
来源
SAO PAULO MEDICAL JOURNAL | 2011年 / 129卷 / 03期
关键词
Bone density; Carotid artery; common; Atherosclerosis; Osteoporosis; Postmenopause; CAROTID PLAQUE ECHOGENICITY; CARDIOVASCULAR-DISEASE; INTERNATIONAL-SOCIETY; OFFICIAL POSITIONS; ARTERIAL-WALL; RISK; ATHEROSCLEROSIS; CALCIFICATION; OSTEOPROTEGERIN; OSTEOPOROSIS;
D O I
10.1590/S1516-31802011000300004
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CONTEXT AND OBJECTIVES: Controversy exists regarding the relationship between atherosclerosis and osteoporosis. The aim of this study was to determine the relationship between intima-media thickness (IMT) of the common carotid artery (CCA), presence of calcified atherosclerotic plaques and bone mineral density (BMD) evaluated by dual energy X-ray absorptiometry (DXA), in postmenopausal women. DESIGN AND SETTING: Cross-sectional study at Second Internal Medicine Clinic, Cluj-Napoca, Romania. METHODS: We studied the IMT (left and right CCA and mean IMT) and T-score (lumbar spine L2-L4, femoral neck and total hip) in 100 postmenopausal women (mean age 64.5 years). The presence of calcified atherosclerotic plaque and osteoporotic vertebral fractures was also noted. RESULTS: IMT in the left and right CCA and mean IMT were significantly associated with T-score measured for the lumbar spine L2-L4, femoral neck and total hip, with lower T-score, in the osteoporotic group than in the normal and osteopenic groups (P < 0.05). IMT had a significantly negative correlation with the lumbar spine T-score and femoral neck T-score; and mean IMT with lowest T-score. Mean IMT (P < 0.001), high blood pressure (P = 0.005) and osteoporotic vertebral fractures (P = 0.048) showed statistical significance regarding the likelihood of developing atherosclerotic plaque. CONCLUSIONS: In women referred for routine osteoporosis screening, the relationship between CCA, atherosclerosis and osteoporosis can be demonstrated using either cortical or trabecular BMD. Vertebral fractures may be considered to be a likelihood factor for atherosclerotic plaque development.
引用
收藏
页码:139 / 145
页数:7
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