Diagnosis of mastocytosis: general histopathological aspects, morphological criteria, and immunohistochemical findings

被引:164
作者
Horny, HP
Valent, P
机构
[1] Med Univ Lubeck, Inst Pathol, D-23538 Lubeck, Germany
[2] Univ Vienna, Div Hematol & Hemostaseol, Dept Internal Med 1, A-1010 Vienna, Austria
关键词
indolent mastocytosis; malignant mastocytosis; mast cell disease; mast cell leukemia; mast cells; mastocytosis; systemic mastocytosis; tryptase;
D O I
10.1016/S0145-2126(01)00021-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
An increase in mast cell (MC) numbers in hemopoietic tissues may be associated with (a) primary neoplastic MC disease (mastocytosis); (b) non-mast cell lineage myelogenous disorders (myelodysplastic or myeloproliferative syndromes and myeloid leukemias); or (c) reactive, i.e. non-clonal states (MC hyperplasia and reactive mastocytosis). However, the histologic discrimination between hyperplastic states and neoplastic MC proliferative disorders is sometimes very difficult. MC hyperplasia is characterized by a diffuse increase in mature, round or spindle-shaped, metachromatic MC that are loosely scattered throughout the tissue and do not form dense focal infiltrates, even in states of marked hyperplasia. However, loosely scattered MC are also a prominent feature of many cases of myelodysplastic syndromes and acute leukemia involving the MC lineage. In contrast, the demonstration of dense, focal and/or diffuse MC infiltrates can be regarded as indicative of primary MC disease/mastocytosis. In addition to the highly diagnostic focal MC infiltrates, mastocytosis may also present with a predominantly diffuse or a mixed (diffuse and focal) infiltration pattern. The relatively rare diffuse pattern is usually dominated by atypical, often hypogranulated or even non-metachromatic MC and is associated with the aggressive or frankly malignant subtypes of systemic mastocytosis and MC leukemia. Although the demonstration of MC infiltrates in Giemsa-stained tissue sections is still very important for the diagnosis of mastocytosis, immunohistochemical techniques using antibodies against MC-associated antigens such as tryptase or c-kit (CD117) are essential for the identification of highly atypical, hypogranulated MC, especially in MC leukemia, and for the detection of small and even minute MC infiltrates. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:543 / 551
页数:9
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