The role of cyclodextrins in chiral capillary electrophoresis

被引：108

作者：

Juvancz, Zoltan ^{[1
]}

Kendrovics, Rita Bodane ^{[1
]}

Ivanyi, Robert ^{[2
]}

Szente, Lajos ^{[2
]}

机构：

[1] Budapest Tech Polytech Inst, Inst Gen Engn & Environm Protect, Rejto Sandor Fac Light Ind, Dept Environm Engn, H-1034 Budapest, Hungary

[2] CycloLab Ltd, Budapest, Hungary

来源：

ELECTROPHORESIS | 2008年 / 29卷 / 08期

关键词：

broad selectivity characters; chiral separations; CDs; trends of chiral applications;

D O I：

10.1002/elps.200700657

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The members of the enantiomeric pairs frequently show rather different biological effects, so their chiral selective synthesis, pharmacological studies and analysis are necessary. CE has unique advantages in chiral analysis. The most frequently used chiral selectors are CDs in this field. This paper gives a short view on the advantages on CE in direct chiral separations, emphasizing the role of CDs. The reason for the broad selectivity spectra of CDs is discussed in detail. The physical background of chiral selective separations is briefly shown in CE. Their interaction mechanisms are shortly defined. The general trend of their use is statistically evaluated. Most frequently used CDs and CD derivatives are characterized. Advantages of ionizable CDs and single-isomer derivatives are shown. The general trend of their use is established.

引用

页码：1701 / 1712

页数：12

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