Glide2, a second glial promoting factor in Drosophila melanogaster

被引：62

作者：

Kammerer, M ^{[1
]}

Giangrande, A ^{[1
]}

机构：

[1] ULP, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch Graffenstaden, CU De Strasbour, France

来源：

EMBO JOURNAL | 2001年 / 20卷 / 17期

关键词：

fly; glial cells; Glide2; Glide; Gcm; transcription factor;

D O I：

10.1093/emboj/20.17.4664

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fly glial cell deficient/glial cell missing (glide/gcm) gene codes for a transcription factor that induces gliogenesis. Lack of its product eliminates lateral glial cells in the embryonic nervous system. Here we identify a second gene, glide2, that is homologous to glide/gcm in the binding domain and that is also necessary and sufficient to promote glial differentiation. glide2 codes for a transcription factor that displays a weaker and delayed expression compared with glide/gcm. The two genes, which are located 27 kb apart and share cis-regulatory elements, are able to auto- and cross-regulate, indicating that they form a gene complex. Finally, we show that lack of both products eliminates all lateral glial cells, which means that the two genes contain all the fly lateral glial promoting activity.

引用

页码：4664 / 4673

页数：10

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