Developmental neurotoxicity - Illustration of principles

被引：12

作者：

Bearer, CF ^{[1
]}

机构：

[1] Case Western Reserve Univ, Cleveland, OH 44106 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2001年 / 48卷 / 05期

关键词：

D O I：

10.1016/S0031-3955(05)70369-2

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

The magnitude of the problem of neurodevelopmental disorders is enormous. Frequently, the mechanism of injury is unknown. In this article, several common developmental neurotoxins are discussed, and the function of one cell adhesion molecule, L1, will be reviewed to illustrate the principles of developmental neurotoxicology. L1 is critical for proper central nervous system development. Similarities between patients with fetal alcohol syndrome and with L1 mutations suggest that the mechanism of developmental neurotoxicity of ethanol is partly due to effects on L1 cell adhesion molecule.

引用

页码：1199 / +

页数：16

共 102 条

[1]

Abel E. L., 1990, FETAL ALCOHOL SYNDRO

[2] AN UPDATE ON INCIDENCE OF FAS - FAS IS NOT AN EQUAL-OPPORTUNITY BIRTH-DEFECT [J].