Testosterone delivery using glutamide-based complex high axial ratio nficrostructures

被引：20

作者：

Goldstein, AS

Amory, JK

Martin, SM

Vernon, C

Matsumoto, A

Yager, P

机构：

[1] Univ Washington, VA Puget Sound Hlth Care Syst, Ctr Geriatr Res Educ & Clin, Seattle, WA 98108 USA

[2] Univ Washington, VA Puget Sound Hlth Care Syst, Gen Internal Med Sect, Seattle, WA 98108 USA

[3] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[4] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[5] Univ Washington, Dept Bioengn, Mol Bioengn Program, Seattle, WA 98195 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2001年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0968-0896(01)00149-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Complex high axial ratio microstructures (CHARMs) were evaluated for delivery of testosterone in vivo. Methods to incorporate testosterone included noncovalent mixing and covalent attachment of testosterone to the lipid to form a prodrug monomer. When prepared by covalent attachment, testosterone-loaded CHARMs were resistant to in vitro spontaneous hydrolysis; when injected into rats, testosterone was released with biphasic kinetics consisting of a burst followed by a much slower phase. Some CHARM material associated with testosterone persisted at the site of injection for at least 9 days. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2819 / 2825

页数：7

共 32 条

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