A selective intramolecular aldol condensation directed by a bifunctional enzyme mimic

被引：22

作者：

Breslow, R

Desper, J

Huang, Y

机构：

[1] Department of Chemistry, Columbia University, New York

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 15期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(96)00337-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intramolecular aldol condensation of a dialdehyde carrying a t-butylphenyl group is almost random with simple imidazole buffer catalysis, but shows a 97% preference for a single regiochemistry of cyclization when the reaction is catalyzed by the imidazole groups of a cyclodextrin-bis-imidazole enzyme mimic. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2541 / 2544

页数：4