Thyroid hormone action: a binding contract

被引：109

作者：

Lazar, MA

机构：

[1] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Dept Med,Penn Diabet Ctr, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Div Endocrinol Diabet & Metab, Dept Genet,Penn Diabet Ctr, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2003年 / 112卷 / 04期

关键词：

D O I：

10.1172/JCI200319479

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Thyroid hormones are critical for differentiation, growth, and metabolism. A new study (see the related article beginning on page 588) investigating the biological role of the TH receptor TR-beta has demonstrated that DNA binding is critical for most of its functions, but also suggests that novel mechanisms independent of DNA binding may contribute to regulation of auditory function by TR-beta.

引用

收藏

页码：497 / 499

页数：3

相关论文

共 21 条

[1] Thyroxine promotes association of mitogen-activated protein kinase and nuclear thyroid hormone receptor (TR) and causes serine phosphorylation of TR [J].

Davis, PJ ;

Shih, A ;

Lin, HY ;

Martino, LJ ;

Davis, FB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :38032-38039

[2] Thyroid hormone receptors: lessons from knockout and knock-in mutant mice [J].

Flamant, F ;

Samarut, J .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2003, 14 (02) :85-90

[3] Thyroid hormone receptor beta is essential for development of auditory function [J].

Forrest, D ;

Erway, LC ;

Ng, L ;

Altschuler, R ;

Curran, T .

NATURE GENETICS, 1996, 13 (03) :354-357

[4]

Glass CK, 2000, GENE DEV, V14, P121

[5] Transcriptional repression by nuclear hormone receptors [J].

Hu, X ;

Lazar, MA .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2000, 11 (01) :6-10

[6] A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors [J].

Kamei, Y ;

Xu, L ;

Heinzel, T ;

Torchia, J ;

Kurokawa, R ;

Gloss, B ;

Lin, SC ;

Heyman, RA ;

Rose, DW ;

Glass, CK ;

Rosenfeld, MG .

CELL, 1996, 85 (03) :403-414

[7] NUCLEAR THYROID-HORMONE RECEPTORS [J].

LAZAR, MA ;

CHIN, WW .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (06) :1777-1782

[8] Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor [J].

Lutz, M ;

Burke, LJ ;

LeFevre, P ;

Myers, FA ;

Thorne, AW ;

Crane-Robinson, C ;

Bonifer, C ;

Filippova, GN ;

Lobanenkov, V ;

Renkawitz, R .

EMBO JOURNAL, 2003, 22 (07) :1579-1587

[9] THE RXR HETERODIMERS AND ORPHAN RECEPTORS [J].

MANGELSDORF, DJ ;

EVANS, RM .

CELL, 1995, 83 (06) :841-850

[10] THE NUCLEAR RECEPTOR SUPERFAMILY - THE 2ND DECADE [J].

MANGELSDORF, DJ ;

THUMMEL, C ;

BEATO, M ;

HERRLICH, P ;

SCHUTZ, G ;

UMESONO, K ;

BLUMBERG, B ;

KASTNER, P ;

MARK, M ;

CHAMBON, P ;

EVANS, RM .

CELL, 1995, 83 (06) :835-839