Ocular perfusion and age-related macular degeneration

被引:54
作者
Ciulla, TA [1 ]
Harris, A [1 ]
Martin, BJ [1 ]
机构
[1] Indiana Univ, Sch Med, Indianapolis, IN USA
来源
ACTA OPHTHALMOLOGICA SCANDINAVICA | 2001年 / 79卷 / 02期
关键词
age-related macular degeneration; ocular perfusion; blood flow; choriod; choriocapillaris; retinal circulation;
D O I
10.1034/j.1600-0420.2001.079002108.x
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To review the role of ocular perfusion in the pathophysiology of age-related macular degeneration (AMD), the leading cause of irreversible blindness in the industrialized world, Methods: Medline search of the literature published in English or with English abstracts from 1966 to 2000 was performed using various combinations of relevant key words, Results: Vascular defects have been identified in both nonexudative and exudative AMD patients using fluorescein angiographic methods, laser Doppler flowmetry, indocyanine green angiography, and color Doppler imaging. Conclusion: Although these studies lend some support to the vascular pathogenesis of AMD, it is not possible to determine if the choroidal perfusion abnormalities play a causative role in nonexudative AMD, if they are simply an association with another primary alteration, such as a primary RPE defect or a genetic defect at the photoreceptor level, or if they are more strongly associated with one particular form of this heterogeneous disease, Further study is warranted.
引用
收藏
页码:108 / 115
页数:8
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