Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

被引：85

作者：

Riveira-Munoz, Eva ^{[3
,22
]}

He, Su-Min ^{[1
,2
,4
,5
]}

Escaramis, Georgia ^{[3
,22
]}

Stuart, Philip E. ^{[6
]}

Hueffmeier, Ulrike ^{[7
]}

Lee, Catherine ^{[8
]}

Kirby, Brian ^{[9
,10
]}

Oka, Akira ^{[11
]}

Giardina, Emiliano ^{[12
]}

Liao, Wilson ^{[13
,14
]}

Bergboer, Judith ^{[15
]}

Kainu, Kati ^{[16
,17
]}

de Cid, Rafael ^{[18
]}

Munkhbat, Batmunkh ^{[19
]}

Zeeuwen, Patrick L. J. M. ^{[15
]}

Armour, John A. L. ^{[20
,21
]}

Poon, Annie ^{[13
,14
]}

Mabuchi, Tomotaka ^{[23
]}

Ozawa, Akira

Zawirska, Agnieszka ^{[9
,10
]}

Burden, A. David ^{[31
]}

Barker, Jonathan N. ^{[8
]}

Capon, Francesca ^{[8
]}

Traupe, Heiko ^{[24
]}

Sun, Liang-Dan ^{[1
,2
,4
,5
]}

Cui, Yong ^{[1
,2
]}

Yin, Xian-Yong ^{[1
,2
]}

Chen, Gang ^{[1
,2
]}

Lim, Henry W. ^{[25
]}

Nair, Rajan P. ^{[6
]}

Voorhees, John J. ^{[6
]}

Tejasvi, Trilokraj ^{[6
]}

Pujol, Ramon ^{[26
]}

Munkhtuvshin, Namid ^{[19
]}

Fischer, Judith ^{[18
]}

Kere, Juha ^{[16
,27
,28
]}

Schalkwijk, Joost ^{[15
]}

Bowcock, Anne M. ^{[29
]}

Kwok, Pui-Yan ^{[13
,14
]}

Novelli, Giuseppe ^{[12
]}

Inoko, Hidetoshi ^{[11
]}

Ryan, Anthony W. ^{[9
,10
]}

Trembath, Richard C. ^{[8
]}

Reis, Andre ^{[7
]}

Zhang, Xue-Jun ^{[1
,2
,5
]}

Elder, James T. ^{[6
,30
]}

Estivill, Xavier ^{[3
,22
]}

机构：

[1] Anhui Med Univ, Hosp 1, Inst Dermatol, Hefei, Anhui, Peoples R China

[2] Anhui Med Univ, Hosp 1, Dept Dermatol, Hefei, Anhui, Peoples R China

[3] CIBERESP, Publ Hlth & Epidemiol Network Biomed Res Ctr, Barcelona, Spain

[4] Minist Educ & Anhui Prov, Key Lab Gene Resource Utilizat Severe Dis, Hefei, Anhui, Peoples R China

[5] Anhui Med Univ, Dept Dermatol & Venerol, Hefei, Anhui, Peoples R China

[6] Univ Michigan, Dept Dermatol, Ann Arbor, MI 48109 USA

[7] Univ Erlangen Nurmberg, Inst Human Genet, Erlangen, Germany

[8] Kings Coll London, Div Genet & Mol Med, London WC2R 2LS, England

[9] Trinity Coll Dublin, St Jamess Hosp, Inst Mol Med, Dublin, Ireland

[10] Trinity Coll Dublin, St Jamess Hosp, Dept Clin Med, Dublin, Ireland

[11] Tokai Univ, Sch Med, Dept Mol Life Sci & Mol Med, Kanagawa 2591100, Japan

[12] Univ Roma Tor Vergata, Sch Med, Ctr Excellence Genom Risk Assessment Multifactori, Dept Biopathol, Rome, Italy

[13] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[14] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[15] Radboud Univ Nijmegen, Med Ctr, Dept Dermatol, NL-6525 ED Nijmegen, Netherlands

[16] Univ Helsinki, Dept Med Genet, Helsinki, Finland

[17] Univ Helsinki, Cent Hosp, Dept Dermatol, FIN-00170 Helsinki, Finland

[18] Ctr Natl Genotypage, Inst Genom, Evry, France

[19] Natl Inst Med, Cent Sci Res Lab, Ulaanbaatar, Mongolia

[20] Univ Nottingham, Queens Med Ctr, Sch Biol, Nottingham NG7 2RD, England

[21] Univ Nottingham, Queens Med Ctr, Inst Genet, Nottingham NG7 2RD, England

[22] CRG, Genes & Dis Programme, Barcelona 08003, Spain

[23] Tokai Univ, Sch Med, Dept Dermatol, Kanagawa 2591100, Japan

[24] Univ Munster, Dept Dermatol, D-4400 Munster, Germany

[25] Henry Ford Hosp, Detroit, MI 48202 USA

[26] Hosp del Mar, IMAS, Dermatol Serv, Barcelona, Spain

[27] Karolinska Inst, Dept Biosci & Nutr, Stockholm, Sweden

[28] Folkhalsan Inst Genet, Helsinki, Finland

[29] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

[30] Ann Arbor Veteran Affairs Med Ctr, Ann Arbor, MI USA

[31] Glasgow Western Infirm, Glasgow, Lanark, Scotland

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 05期

基金：

芬兰科学院; 英国惠康基金; 中国国家自然科学基金; 英国医学研究理事会; 美国国家卫生研究院;

关键词：

SUSCEPTIBILITY; GENES; LCE3B;

D O I：

10.1038/jid.2010.350

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OROverall = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

引用

页码：1105 / 1109

页数：5

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