Combining exercise and cyclooxygenase-2 inhibition does not ameliorate learning deficits after brain insult, despite an increase in BDNF levels

被引：8

作者：

Gobbo, OL

O'Mara, SM ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Dept Psychol, Dublin 2, Ireland

[2] Univ Dublin Trinity Coll, Inst Neurosci, Dublin 2, Ireland

来源：

BRAIN RESEARCH | 2005年 / 1046卷 / 1-2期

关键词：

running; celecoxib; watermaze; object displacement;

D O I：

10.1016/j.brainres.2005.03.046

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neurodegeneration can produce behavioral impairments. Previously, we have found that inhibition of cyclooxygenase-2 activity or physical activity was neuroprotective during kainic-acid-induced neural loss. Here, we investigated the combined effect of exercise pre-insult and cyclooxygenase inhibitor treatment post-kainate-induced brain damage. However, in spite of an increase in BDNF levels, the combination did not improve behavioral performance in Morris watermaze and object exploration tasks. (c) 2005 Elsevier B.V. All rights reserved.

引用

收藏

页码：224 / 229

页数：6

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