Real-time tracking of self-reported symptoms to predict potential COVID-19

被引：801

作者：

Menni, Cristina ^{[1
]}

Valdes, Ana M. ^{[1
,2
]}

Freidin, Maxim B. ^{[1
]}

Sudre, Carole H. ^{[3
]}

Nguyen, Long H. ^{[4
,5
]}

Drew, David A. ^{[4
,5
]}

Ganesh, Sajaysurya ^{[6
]}

Varsavsky, Thomas ^{[3
]}

Cardoso, M. Jorge ^{[3
]}

Moustafa, Julia S. El-Sayed ^{[1
]}

Visconti, Alessia ^{[1
]}

Hysi, Pirro ^{[1
]}

Bowyer, Ruth C. E. ^{[1
]}

Mangino, Massimo ^{[1
,7
]}

Falchi, Mario ^{[1
]}

Wolf, Jonathan ^{[6
]}

Ourselin, Sebastien ^{[3
]}

Chan, Andrew T. ^{[4
,5
]}

Steves, Claire J. ^{[1
]}

Spector, Tim D. ^{[1
]}

机构：

[1] Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England

[2] Nottingham City Hosp, Acad Rheumatol, Clin Sci, Nottingham, England

[3] Kings Coll London, Sch Biomed Engn & Imaging Sci, London, England

[4] Massachusetts Gen Hosp, Clin & Translat Epidemiol Unit, Boston, MA 02114 USA

[5] Harvard Med Sch, Boston, MA 02115 USA

[6] Zoe Global, London, England

[7] Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England

来源：

NATURE MEDICINE | 2020年 / 26卷 / 07期

基金：

英国工程与自然科学研究理事会; 英国惠康基金; 英国医学研究理事会; 英国科研创新办公室;

关键词：

D O I：

10.1038/s41591-020-0916-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those with a positive test result (4,668 of 7,178 individuals; 65.03%) than in those with a negative test result (2,436 of 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval = 6.31-7.21). A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19. Analysis of data from a smartphone-based app designed for large-scale tracking of potential COVID-19 symptoms, used by over 2.5 million participants in the United Kingdom and United States, shows that loss of taste and smell sensations is predictive of potential SARS-CoV-2 infection.

引用

页码：1037 / +

页数：8

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