CARDIODETECT RAPID TEST FOR THE DIAGNOSIS OF EARLY ACUTE MYOCARDIAL INFARCTION

被引：11

作者：

Liang, Yan ^{[1
,2
]}

Chan, Cangel P. Y. ^{[3
]}

Cheung, Kwan-yee ^{[4
]}

Cautherley, George W. H. ^{[4
]}

Glatz, Jan F. C. ^{[5
]}

Renneberg, Reinhard ^{[6
]}

Zhu, Jun ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Dept Emergency, Cardiovasc Inst, Peking Union Med Coll, Beijing 100037, Peoples R China

[2] Chinese Acad Med Sci, FuWai Hosp, Peking Union Med Coll, Beijing 100037, Peoples R China

[3] Chinese Univ Hong Kong, Accid & Emergency Med Acad Unit, Prince Wales Hosp, Hong Kong, Hong Kong, Peoples R China

[4] R&C Biogenius Ltd, Hong Kong, Hong Kong, Peoples R China

[5] Maastricht Univ, Dept Mol Genet, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands

[6] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF IMMUNOASSAY & IMMUNOCHEMISTRY | 2011年 / 32卷 / 04期

关键词：

acute myocardial infarction; cardiac marker; cardiac troponin I; diagnosis; heart-type fatty acid-binding protein; myoglobin; ACID-BINDING PROTEIN; TISSUE-INJURY; MARKERS; IMMUNOSENSORS; IMMUNOTESTS;

D O I：

10.1080/15321819.2011.573043

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Two hundreds patients suspected of acute myocardial infarction presenting to the hospital with a median symptom onset of 2.3 h (IQR 1.7-4.0 h) were enrolled in this study. The diagnostic performances of CardioDetect (R), a one-step immunotest for heart-type fatty acid-binding protein (H-FABP), and its combination with cardiac troponin I (cTnI) at admission and 2 h after admission, were compared with different cardiac markers. The H-FABP immunotest had better sensitivities (76.6% and 94.4%) than the other cardiac markers and better specificities (88.2% and 81.7%) than myoglobin at admission and 2 h after admission. Both sensitivity and negative predictive value increased to over 90.0% at 2 h after admission. The areas under the receiver operator characteristic curve for the combination of H-FABP with cTnI were the greatest at admission [0.834 (95% CI: 0.774-0.894)].

引用

页码：342 / 352

页数：11

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