Synthesis of 2-(alkylamino)benzimidazoles

被引：55

作者：

Perkins, JJ ^{[1
]}

Zartman, AE ^{[1
]}

Meissner, RS ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(98)02592-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A general and highly convenient procedure for the synthesis of 2(alkylamino)benzimidazoles has been developed and a variety of analogs have been efficiently prepared. Included is a dipeptide mimetic in which the guanidine group of an arginine residue has been replaced with a 2-aminobenzimidazole. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1103 / 1106

页数：4

共 9 条

[1]

BERA T, 1992, INDIAN J CHEM B, V6, P370

[2]

CHOW AW, 1969, Patent No. 3468888

[3] NEW ANTIHISTAMINIC N-HETEROCYCLIC 4-PIPERIDINAMINES .1. SYNTHESIS AND ANTIHISTAMINIC ACTIVITY OF N-(4-PIPERIDINYL)-1H-BENZIMIDAZOL-2-AMINES [J].

JANSSENS, F ;

TORREMANS, J ;

JANSSEN, M ;

STOKBROEKX, RA ;

LUYCKX, M ;

JANSSEN, PAJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1925-1933

[4]

KIFTER D, 1968, CR ACAD SCI C CHIM, V267, P1730

[5]

OJHA V, 1993, INDIAN J CHEM B, V3, P394

[6]

OMAR ME, 1974, SYNTHESIS-STUTTGART, P41

[7]

RASTOGI R, 1983, SYNTHESIS-STUTTGART, P861

[8]

Simonov A. M., 1979, CHEM HETEROCYCL COMP, V15, P705

[9]

STEDMAN RJ, 1969, Patent No. 3455948

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