Convenient preparation of N-substituted indoles by modified Leimgruber-Batcho indole synthesis

被引：23

作者：

Coe, JW

Vetelino, MG

Bradlee, MJ

机构：

[1] Central Research Division, Pfizer Inc, Groton

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 34期

关键词：

D O I：

10.1016/0040-4039(96)01311-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A modified reductive alkylation of pre-indole 3, prepared from readily available Leimgruber-Batcho indole synthesis derived intermediates, followed by acidic methanolysis generates 6-carbomethoxy-N-substituted indoles. The three step preparation of pre-indole 3 from substituted 2-nitrotoluene I in 66% yield and conversion of a variety of N-substituted indoles is presented. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6045 / 6048

页数：4

共 30 条

[1] Reductive amination of aldehydes and ketones with sodium triacetoxyborohydride. Studies on direct and indirect reductive amination procedures [J].