Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

被引：357

作者：

Shukla, Arun K. ^{[1
,2
]}

Xiao, Kunhong ^{[1
]}

Lefkowitz, Robert J. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Howard Hughes Med Inst, Durham, NC 27710 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2011年 / 36卷 / 09期

基金：

美国国家卫生研究院;

关键词：

PROTEIN-COUPLED RECEPTOR; BETA(2)-ADRENERGIC RECEPTOR; 7-TRANSMEMBRANE RECEPTORS; PHOSPHATIDYLINOSITOL; 3-KINASE; CONFORMATIONAL-CHANGES; CRYSTAL-STRUCTURE; BETA-2-ADRENERGIC RECEPTOR; ACTIVATED RECEPTOR-2; CLATHRIN ADAPTER; VISUAL ARRESTIN;

D O I：

10.1016/j.tibs.2011.06.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Arrestins, originally discovered to desensitize activated seven transmembrane receptors (7TMRs; also known as G-protein-coupled receptors, GPCRs), are now well established mediators of receptor endocytosis, ubiquitylation and G protein-independent signaling. Recent global analyses of beta-arrestin interactions and beta-arrestin-dependent phosphorylation events have uncovered several previously unanticipated roles of beta-arrestins in a range of cellular signaling events. These findings strongly suggest that the functional roles of beta-arrestins are much broader than currently understood. Biophysical studies aimed at understanding multiple active conformations of the 7TMRs and the beta-arrestins have begun to unravel the mechanistic basis for the diverse functional capabilities of beta-arrestins in cellular signaling.

引用

页码：457 / 469

页数：13

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