B cell development and receptor diversity during aging

被引：69

作者：

Allman, D ^{[1
]}

Miller, JP ^{[1
]}

机构：

[1] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 05期

关键词：

D O I：

10.1016/j.coi.2005.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although it is clear that B cell genesis declines with age, the specifics of why this happens are largely unknown. Even less clear is how the age-related decline in B cell development might affect peripheral B cell function. Recent studies have investigated the impact of aging on both B cell genesis in the bone marrow and the resulting peripheral B cell repertoire. On the basis of these studies we propose a model in which the aging of very early B cell progenitors results in shifts in the peripheral B cell repertoire and, consequently, changes in mature B cell function.

引用

页码：463 / 467

页数：5

共 35 条

[1] An invitation to T and more: Notch signaling in lymphopoiesis [J].

Allman, D ;

Punt, JA ;

Izon, DJ ;

Aster, JC ;

Pear, WS .

CELL, 2002, 109 :S1-S11

[2] B1b lymphocytes confer T cell-independent long-lasting immunity [J].

Alugupalli, KR ;

Leong, JM ;

Woodland, RT ;

Muramatsu, M ;

Honjo, T ;

Gerstein, RM .

IMMUNITY, 2004, 21 (03) :379-390

[3] Transcriptional control of early B cell development [J].

Busslinger, M .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :55-79

[4] If you would live long, choose your parents well [J].

Cournil, A ;

Kirkwood, TBL .

TRENDS IN GENETICS, 2001, 17 (05) :233-235

[5] Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway [J].

Fleming, HE ;

Paige, CJ .

IMMUNITY, 2001, 15 (04) :521-531

[6] Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system [J].

Greenbaum, S ;

Zhuang, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (23) :15030-15035

[7] Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow [J].

Hao, ZY ;

Rajewsky, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (08) :1151-1163

[8] Selection during development of VH11+B cells:: a model for natural autoantibody-producing CD5+ B cells [J].

Hardy, RR ;

Wei, CJ ;

Hayakawa, K .

IMMUNOLOGICAL REVIEWS, 2004, 197 :60-74

[9] B cell development pathways [J].

Hardy, RR ;

Hayakawa, K .

ANNUAL REVIEW OF IMMUNOLOGY, 2001, 19 :595-621

[10] Stochastic and genetic factors influence tissue-specific decline in ageing C-elegans [J].

Herndon, LA ;

Schmeissner, PJ ;

Dudaronek, JM ;

Brown, PA ;

Listner, KM ;

Sakano, Y ;

Paupard, MC ;

Hall, DH ;

Driscoll, M .

NATURE, 2002, 419 (6909) :808-814

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