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Evolutionary changes in mutation rates and spectra and their influence on the adaptation of pathogens

被引：19
作者：
Metzgar, D
Wills, C
机构：
[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Ctr Genet Mol, La Jolla, CA 92093 USA
来源：
MICROBES AND INFECTION | 2000年 / 2卷 / 12期
基金：
美国国家航空航天局;
关键词：
mutagenesis; evolution; host-parasite relations; biological adaptation; drug resistance;
D O I：
10.1016/S1286-4579(00)01306-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The evolutionary tuning of mutational processes may play a key role in prokaryotic evolution, particularly among pathogens. In this paper we review the evidence that genetic systems controlling the rate and spectrum of heritable mutations have evolved to optimize levels of adaptive variation and rates of genetic change. (C) 2000 Editions scientifiques et medicales Elsevier SAS.
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收藏
页码：1513 / 1522
页数：10
相关论文
共 73 条
  • [1] Against all odds: The survival strategies of Deinococcus radiodurans
    Battista, JR
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 1997, 51 : 203 - 224
  • [2] Borst P, 1996, ARCH MED RES, V27, P379
  • [3] Borst P, 1997, Behring Inst Mitt, P1
  • [4] Hypermutation in pathogenic bacteria: Frequent phase variation in meningococci is a phenotypic trait of a specialized mutator biotype
    Bucci, C
    Lavitola, A
    Salvatore, P
    Del Giudice, L
    Massardo, DR
    Bruni, CB
    Alifano, P
    [J]. MOLECULAR CELL, 1999, 3 (04) : 435 - 445
  • [5] THE ORIGIN OF MUTANTS
    CAIRNS, J
    OVERBAUGH, J
    MILLER, S
    [J]. NATURE, 1988, 335 (6186) : 142 - 145
  • [6] CAIRNS J, 1991, GENETICS, V128, P695
  • [7] To be a mutator, or how pathogenic and commensal bacteria can evolve rapidly - Response
    Cebula, TA
    LeClerc, JE
    [J]. TRENDS IN MICROBIOLOGY, 1997, 5 (11) : 428 - 429
  • [8] CHAO L, 1983, EVOLUTION, V37, P125, DOI 10.1111/j.1558-5646.1983.tb05521.x
  • [9] Dawkins R., 1986, BLIND WATCHMAKER
  • [10] Diminishing returns from mutation supply rate in asexual populations
    de Visser, JAGM
    Zeyl, CW
    Gerrish, PJ
    Blanchard, JL
    Lenski, RE
    [J]. SCIENCE, 1999, 283 (5400) : 404 - 406
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