Distribution of porcine CD4/CD8 double-positive T lymphocytes in mucosa-associated lymphoid tissues

被引:270
作者
Zuckermann, FA [1 ]
Gaskins, HR [1 ]
机构
[1] UNIV ILLINOIS, DEPT ANIM SCI, URBANA, IL 61801 USA
关键词
D O I
10.1046/j.1365-2567.1996.494570.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The present study describes the distribution of CD4/CD8 double-positive (DP) T cells in lymph nodes and mucosa-associated lymphoid tissues of pigs at 6-7 months of age. Proportions of lymphocytes isolated from peripheral, bronchial and mesenteric lymph nodes expressing CD4 and/or CD8 molecules were similar and ranged from 10-13% CD4/CD8 DP cells, 25-27% CD4 single-positive (SP) cells, and 27-32% CD8 SP cells. Mucosa-associated lymphoid tissues had significantly smaller proportions of CD4(+) and/or CD8(+) T cells than lymph nodes and CD4/CD8 DP cells accounted for a larger proportion of the total CD4(+) lymphocytes than in lymph nodes. Compared to the lymph nodes, the predominant CD4(+) and/or CD8(+) T-cell subset in tonsils was the CD4/CD8 DP population (18%), because of both a higher proportion of these cells and a lower proportion of CD4 SP (12%) and CD8 SP (14%) lymphocyte subsets. Jejunal Peyer's patches were comprised of 12% CD4 SP, 28% CD8 SP and 10% CD4/CD8 DP lymphocytes. In contrast, the mid-section of the continuous Peyer's patch in the ileum contained 7% CD4 SP, 8% CD8 SP and 4% CD4/CD8 DP lymphocytes. The distribution of T lymphocytes in porcine mucosal lymphoid aggregates agrees with the reported correlation between high and low rates of lymphocyte entry into these tissues and the abundance or scarcity of T cells, respectively. Defining the role of CD4/CD8 DP lymphocytes and their unique distribution in mucosa-associated lymphoid tissues in the pig may reveal novel T-cell-mediated regulatory pathways.
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页码:493 / 499
页数:7
相关论文
共 38 条
[1]  
BERNSTEIN JM, 1994, HDB MUCOSAL IMMUNOLO, P625
[2]   DEVELOPMENT OF THE B-CELL AND T-CELL COMPARTMENTS IN PORCINE LYMPHOID ORGANS FROM BIRTH TO ADULT LIFE - AN IMMUNOHISTOLOGICAL APPROACH [J].
BIANCHI, ATJ ;
ZWART, RJ ;
JEURISSEN, SHM ;
MOONENLEUSEN, HWM .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1992, 33 (03) :201-221
[3]  
BINNS RM, 1992, IMMUNOLOGY, V77, P219
[4]   THE NULL/GAMMA-DELTA-TCR(+) T-CELL FAMILY IN THE PIG [J].
BINNS, RM .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 43 (1-3) :69-77
[5]   LYMPHOID-TISSUE STRUCTURE AND LYMPHOCYTE TRAFFICKING IN THE PIG [J].
BINNS, RM ;
PABST, R .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 1994, 43 (1-3) :79-87
[6]  
BINNS RM, 1985, MICROENVIRONMENTS LY, P661
[7]  
BLUE ML, 1986, J IMMUNOL, V137, P1202
[8]  
BLUE ML, 1985, J IMMUNOL, V134, P2281
[9]   CHARACTERISTICS OF EARLY ROUTINE RENAL-ALLOGRAFT BIOPSIES [J].
BURDICK, JF ;
BESCHORNER, WE ;
SMITH, WJ ;
MCGRAW, D ;
BENDER, WL ;
WILLIAMS, GM ;
SOLEZ, K .
TRANSPLANTATION, 1984, 38 (06) :679-684
[10]   CD3+4-8-WT31- (T-CELL RECEPTOR-GAMMA+) CELLS AND OTHER UNUSUAL PHENOTYPES ARE FREQUENTLY DETECTED AMONG SPONTANEOUSLY INTERLEUKIN 2-RESPONSIVE LYMPHOCYTES-T PRESENT IN THE JOINT FLUID IN JUVENILE RHEUMATOID-ARTHRITIS - A CLONAL ANALYSIS [J].
DEMARIA, A ;
MALNATI, M ;
MORETTA, A ;
PENDE, D ;
BOTTINO, C ;
CASORATI, G ;
COTTAFAVA, F ;
MELIOLI, G ;
MINGARI, MC ;
MIGONE, N ;
ROMAGNANI, S ;
MORETTA, L .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1987, 17 (12) :1815-1819