Large-scale manufacture of peptide therapeutics by chemical synthesis

被引：475

作者：

Bray, BL ^{[1
]}

机构：

[1] Trimeris Inc, Durham, NC 27707 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2003年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrd1133

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The large-scale commercial production of a 36-amino-acid peptide by chemical synthesis has been demonstrated in the development of enfuvirtide (T-20 or Fuzeon), a first-in-class membrane fusion inhibitor for the treatment of HIV. The rationale behind route selection and the scale-up of the process used to manufacture enfuvirtide are discussed.

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页码：587 / 593

页数：7

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