Comparative analysis of mu-opioid receptor expression in immune and neuronal cells

被引：54

作者：

Boerner, Christine ^{[1
]}

Stumm, Ralf ^{[1
]}

Hoellt, Volker ^{[1
]}

Kraus, Juergen ^{[1
]}

机构：

[1] Univ Magdeburg, Dept Pharmacol & Toxicol, D-39120 Magdeburg, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2007年 / 188卷 / 1-2期

关键词：

lymphocyte; neuron; mu-opioid receptor; interleukin-4; mitogen activated protein kinase; tumor necrosis factor;

D O I：

10.1016/j.jneuroim.2007.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Morphine modulates neuronal and immune cell functions via [mu-opioid receptors. In primary and Jurkat T cells, and Raji B cells P-opioid receptor transcripts were detected only after stimulation of the cells with IL-4 or TNF-alpha. Moreover, the amount of the induced It-opioid receptor mRNA in the immune cells was 15 to 200 times less than those in primary cortical and SH SY5Y neuronal cells. Nevertheless, P-opioid receptor mRNA in immune cells is processed to functional receptors, as demonstrated by morphine-mediated phosphorylation of mitogen activated protein kinase, morphine-mediated up-regulation of IL-4 mRNA and coupling to adenylyl cyclase in Jurkat cells. (c) 2007 Elsevier B.V All rights reserved.

引用

页码：56 / 63

页数：8

共 37 条

[1] HIV-1 gp120 up-regulation of the mu opioid receptor in TPA-differentiated HL-60 cells [J].

Beltran, Jose A. ;

Pallur, Anitha ;

Chang, Sulie L. .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2006, 6 (09) :1459-1467

[2] Transcriptional regulation of the human μ-opioid receptor gene by interleukin-6 [J].

Börner, C ;

Kraus, J ;

Schröder, H ;

Ammer, H ;

Höllt, V .

MOLECULAR PHARMACOLOGY, 2004, 66 (06) :1719-1726

[3] Cannabinoid receptor type 2 Agonists induce transcription of the μ-opioid receptor gene in Jurkat T cells [J].

Börner, C ;

Höllt, V ;

Kraus, J .

MOLECULAR PHARMACOLOGY, 2006, 69 (04) :1486-1491

[4] Involvement of activator protein-1 in transcriptional regulation of the human μ-opioid receptor gene [J].

Börner, C ;

Höllt, V ;

Kraus, J .

MOLECULAR PHARMACOLOGY, 2002, 61 (04) :800-805

[5] IMMUNOLOGICAL DYSFUNCTION IN HEROIN-ADDICTS [J].

BROWN, SM ;

STIMMEL, B ;

TAUB, RN ;

KOCHWA, S ;

ROSEFIELD, RE .

ARCHIVES OF INTERNAL MEDICINE, 1974, 134 (06) :1001-1006

[6] Transcriptional regulation of cytosol and membrane alanyl-aminopeptidase in human T cell subsets [J].

Bukowska, A ;

Tadje, J ;

Arndt, M ;

Wolke, C ;

Kähne, T ;

Bartsch, J ;

Faust, J ;

Neubert, K ;

Hashimoto, Y ;

Lendeckel, U .

BIOLOGICAL CHEMISTRY, 2003, 384 (04) :657-665

[7] Induction and activation of mitogen-activated protein kinases of human lymphocytes as one of the signaling pathways of the immunomodulatory effects of morphine sulfate [J].

Chuang, LF ;

Killam, KF ;

Chuang, RY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (43) :26815-26817

[8] Abolition of morphine-immunosuppression in mice lacking the μ-opioid receptor gene [J].

Gavériaux-Ruff, C ;

Matthes, HWD ;

Peluso, J ;

Kieffer, BL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6326-6330

[9] Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells [J].

Horner, KA ;

Zadina, JE .

BRAIN RESEARCH, 2004, 1028 (02) :121-132

[10] T cell receptor signaling: Beyond complex complexes [J].

Huang, YP ;

Wange, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (28) :28827-28830

← 1 2 3 4 →