Thrombotic microangiopathy after combined autografting-allografting for multiple myeloma - report of three cases

被引：11

作者：

Kornacker, M ^{[1
]}

Luft, T ^{[1
]}

Ho, AD ^{[1
]}

Schaefer, HJ ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Med 5, Heidelberg, Germany

来源：

EUROPEAN JOURNAL OF HAEMATOLOGY | 2005年 / 74卷 / 03期

关键词：

thrombotic microangiopathy; endothelial damage; stem cell transplantation; multiple myeloma;

D O I：

10.1111/j.1600-0609.2004.00372.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thrombotic microangiopathy (TMA) has been described as a complication of bone marrow or stem cell transplantation. It is usually associated with high dose therapy for autologous transplantation or myeloablative conditioning in the allogeneic setting. Here we report three cases of TMA after reduced intensity conditioning and allogeneic peripheral blood stem cell transplantation. All three patients had high dose Melphalan therapy with autologous stem cell support preceding the allogeneic transplantation for several weeks, which may have contributed to endothelial damage and subsequent development of TMA.

引用

收藏

页码：250 / 253

页数：4

相关论文

共 10 条

[1] Defibrotide as a promising treatment for thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation [J].

Corti, P ;

Uderzo, C ;

Tagliabue, A ;

Della Volpe, A ;

Annaloro, C ;

Tagliaferri, E ;

Balduzzi, A .

BONE MARROW TRANSPLANTATION, 2002, 29 (06) :542-543

[2] Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide [J].

Eissner, G ;

Multhoff, G ;

Gerbitz, A ;

Kirchner, S ;

Bauer, S ;

Haffner, S ;

Sondermann, D ;

Andreesen, R ;

Holler, E .

BLOOD, 2002, 100 (01) :334-340

[3] Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation [J].

Fassas, ABT ;

Buddharaju, LN ;

Rapoport, A ;

Cottler-Fox, M ;

Drachenberg, C ;

Meisenberg, B ;

Tricot, G .

LEUKEMIA & LYMPHOMA, 2001, 42 (04) :801-+

[4] ENDOTHELIAL PROLIFERATION IN TUMORS AND NORMAL-TISSUES - CONTINUOUS LABELING STUDIES [J].

HOBSON, B ;

DENEKAMP, J .

BRITISH JOURNAL OF CANCER, 1984, 49 (04) :405-413

[5] Severe thrombotic microangiopathy: an infrequent complication of bone marrow transplantation [J].

Iacopino, P ;

Pucci, G ;

Arcese, W ;

Bosi, A ;

Falda, M ;

Locatelli, F ;

Marenco, P ;

Miniero, R ;

Morabito, F ;

Rossetti, F ;

Sica, S ;

Uderzo, C ;

Bacigalupo, A .

BONE MARROW TRANSPLANTATION, 1999, 24 (01) :47-51

[6] Haematopoietic stem cell transplantation with non-myeloablative conditioning in the outpatient setting: results, complications and admission requirements in a single institution [J].

Petersen, SL ;

Madsen, HO ;

Ryder, LP ;

Svejgaard, A ;

Jakobsen, BK ;

Sengelov, H ;

Heilmann, C ;

Dickmeiss, E ;

Vindelov, LL .

BRITISH JOURNAL OF HAEMATOLOGY, 2004, 125 (02) :225-231

[7]

PETTITT AR, 1994, BONE MARROW TRANSPL, V14, P495

[8] Thrombotic thrombocytopenic purpura after allogeneic stem cell transplantation: a survey of the European Group for Blood and Marrow Transplantation (EBMT) [J].

Ruutu, T ;

Hermans, J ;

Niederwieser, D ;

Gratwohl, A ;

Kiehl, M ;

Volin, L ;

Bertz, H ;

Ljungman, P ;

Spence, D ;

Verdonck, LF ;

Prentice, HG ;

Bosi, A ;

du Toit, CE ;

Brinch, L ;

Apperley, JF .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (04) :1112-1119

[9] Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced-intensity conditioning: The incidence is not reduced [J].

Shimoni, A ;

Yeshurun, M ;

Hardan, I ;

Avigdor, A ;

Ben-Bassat, I ;

Nagler, AN .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2004, 10 (07) :484-493

[10]

ZEIGLER ZR, 1995, BONE MARROW TRANSPL, V15, P247