Near-field scanner for moving molecules

被引:60
作者
Tegenfeldt, JO [1 ]
Bakajin, O
Chou, CF
Chan, SS
Austin, R
Fann, W
Liou, L
Chan, E
Duke, T
Cox, EC
机构
[1] Princeton Univ, Dept Phys, Princeton, NJ 08544 USA
[2] Natl Taiwan Univ, Dept Phys, Taipei 10764, Taiwan
[3] Acad Sinica, Inst Atom & Mol Sci, Taipei 115, Taiwan
[4] Natl Taiwan Univ, Taipei 10764, Taiwan
[5] US Genom, Woburn, MA 01801 USA
[6] Univ Cambridge, Cavendish Lab, Cambridge CB3 0HE, England
[7] Princeton Univ, Dept Biol Mol, Princeton, NJ 08544 USA
关键词
D O I
10.1103/PhysRevLett.86.1378
中图分类号
O4 [物理学];
学科分类号
0702 ;
摘要
We have fabricated using electron beam nanolithography a fixed slit near-held optical scanning device which uses near-field fluorimetry to achieve 200 nm spatial resolution of objects moving over the slits. We explore the basic physics of operating narrow slits in the waveguide cutoff mode and present data from the passage of extended double-stranded DNA molecules passing over the slits as a first example of how this device can be used to do ultrahigh spatial resolution mapping of long polymers.
引用
收藏
页码:1378 / 1381
页数:4
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