Subtype C is associated with increased vaginal shedding of HIV-1

被引：61

作者：

John-Stewart, GC

Nduati, RW

Rousseau, CM

Mbori-Ngacha, DA

Richardson, BA

Rainwater, S

Panteleeff, DD

Overbaugh, J

机构：

[1] Univ Washington, IARTP, Dept Med, Seattle, WA 98104 USA

[2] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

[3] Univ Washington, Dept Epidemiol, Seattle, WA 98104 USA

[4] Fred Hutchinson Canc Res Ctr, Div Human Biol, Seattle, WA 98104 USA

[5] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[6] Univ Nairobi, Dept Paediat, Nairobi, Kenya

来源：

JOURNAL OF INFECTIOUS DISEASES | 2005年 / 192卷 / 03期

关键词：

D O I：

10.1086/431514

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of human immunodeficiency virus (HIV)-1 infected cells and HIV-1 RNA levels in genital secretions and breast milk and the risk of mother-to-child transmission of HIV-1 were compared among subtypes A, C, and D in a Kenyan cohort. Pregnant women infected with subtype C were significantly more likely to shed HIV-1-infected vaginal cells than were those infected with subtype A or D ( odds ratio [ OR], 3.6 [95% confidence interval {CI}, 1.4-8.8]; P p. 006). This relationship held after adjusting for age, CD4 cell count, and plasma HIV-1 RNA load (OR, 3.1 [ 95% CI,1.1-8.6];). These observations suggest that HIV-1 Pp. 03 subtype influences mucosal shedding of HIV-1.

引用

页码：492 / 496

页数：5

共 15 条

[1] PROSPECTIVE COMPARISON OF MOTHER-TO-CHILD TRANSMISSION OF HIV-1 AND HIV-2 IN ABIDJAN, IVORY-COAST [J].

ADJORLOLOJOHNSON, G ;

DECOCK, KM ;

EKPINI, E ;

VETTER, KM ;

SIBAILLY, T ;

BRATTEGAARD, K ;

YAVO, D ;

DOORLY, R ;

WHITAKER, JP ;

KESTENS, L ;

OU, CY ;

GEORGE, JR ;

GAYLE, HD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 272 (06) :462-466

[2] HIV-1 LTR subtype and perinatal transmission [J].

Blackard, JT ;

Renjifo, B ;

Fawzi, W ;

Hertzmark, E ;

Msamanga, G ;

Mwakagile, D ;

Hunter, D ;

Spiegelman, D ;

Sharghi, N ;

Kagoma, C ;

Essex, M .

VIROLOGY, 2001, 287 (02) :261-265

[3] Sequence variability of the integrase protein from a diverse collection of HIV type 1 isolates representing several subtypes [J].

Burns, CC ;

Gleason, LM ;

Mozaffarian, A ;

Giachetti, C ;

Carr, JK ;

Overbaugh, J .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2002, 18 (14) :1031-1041

[4] Evaluation of performance of the Gen-Probe human immunodeficiency virus type 1 viral load assay using primary subtype A, C, and D isolates from Kenya [J].

Emery, S ;

Bodrug, S ;

Richardson, BA ;

Giachetti, C ;

Bott, MA ;

Panteleeff, D ;

Jagodzinski, LL ;

Michael, NL ;

Nduati, R ;

Bwayo, J ;

Kreiss, JK ;

Overbaugh, J .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (07) :2688-2695

[5] Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 study) [J].

Eshleman, SH ;

Becker-Pergola, G ;

Deseyve, M ;

Guay, LA ;

Mracna, M ;

Fleming, T ;

Cunningham, S ;

Musoke, P ;

Mmiro, F ;

Jackson, JB .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (07) :914-917

[6] The associations between cervicovaginal HIV shedding, sexually transmitted diseases and immunosuppression in female sex workers in Abidjan, Cote d'Ivoire [J].

Ghys, PD ;

Fransen, K ;

Diallo, MO ;

EttiegneTraore, V ;

Coulibaly, IM ;

Yeboue, KM ;

Kalish, ML ;

Maurice, C ;

Whitaker, JP ;

Greenberg, AE ;

Laga, M .

AIDS, 1997, 11 (12) :F85-F93

[7] Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: Association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections [J].

John, GC ;

Nduati, RW ;

Mbori-Ngacha, DA ;

Richardson, BA ;

Panteleeff, D ;

Mwatha, A ;

Overbaugh, J ;

Bwayo, J ;

Ndinya-Achola, JO ;

Kreiss, JK .

JOURNAL OF INFECTIOUS DISEASES, 2001, 183 (02) :206-212

[8] Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1-positive persons in Uganda [J].

Kaleebu, P ;

French, N ;

Mahe, C ;

Yirrell, D ;

Watera, C ;

Lyagoba, F ;

Nakiyingi, J ;

Rutebemberwa, A ;

Morgan, D ;

Weber, J ;

Gilks, C ;

Whitworth, J .

JOURNAL OF INFECTIOUS DISEASES, 2002, 185 (09) :1244-1250

[9] Human immunodeficiency virus type 1 subtypes differ in disease progression [J].

Kanki, PJ ;

Hamel, DJ ;

Sankalé, JL ;

Hsieh, CC ;

Thior, I ;

Barin, F ;

Woodcock, SA ;

Guèye-Ndiaye, A ;

Zhang, E ;

Montano, M ;

Siby, T ;

Marlink, R ;

NDoye, I ;

Essex, ME .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (01) :68-73

[10]

KUNANUSONT C, 1995, LANCET, V345, P1078, DOI 10.1016/S0140-6736(95)90818-8

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