Insulin resistance in cognitive impairment - The InCHIANTI study

Objective: To test the association between cognitive impairment, with and without subcortical features, and insulin resistance in an elderly community-dwelling population. Design: Cross-sectional wave of an epidemiologic longitudinal study (InCHIANTI). Participants: A total of 523 people, aged 70 to 90 years without diabetes mellitus or hyperglycemia, from the InCHIANTI cohort were included in the study. A total of 119 individuals had cognitive impairment (MiniMental State Examination [MMSE] score < 25), 21 of whom had both cognitive impairment and subcortical features (CI/SF+ group). Control groups contained 23 individuals with a history of stroke and 381 individuals with no cognitive impairment (no CI group, MMSE score >= 25). Indicators of insulin resistance were the fasting plasma insulin level, insulin resistance index (Homeostasis Model Assessment of Insulin Resistance [HOMA-IR]), and insulin sensitivity index (Quantitative Insulin Sensitivity Check Index [QUICKI]).