Some benzenesulfonamido-substituted valerophenones that are selective antagonists for the 5-HT2C receptor

被引：13

作者：

Weinhardt, KK

Bonhaus, DW

DeSouza, A

机构：

[1] Roche Bioscience, Neurobiology Unit, Palo Alto, CA 94304-1397

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(96)00503-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Substituted benzenesulfonyl derivatives of m-aminovalerophenones bearing a 1,3,8-triazaspiro[4.5]decane-2,4-dione at the all;yl terminus are the first known, selective Ligands for the 5-HT2C receptor. A brief structure-activity relationship of this series is outlined. Copyright (C) 1996 Elsevier Science Ltd

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页码：2687 / 2692

页数：6

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