The synthesis of [2.2.2]bicyclooctane and [3.1.1]bicycloheptane based amino acids as constrained glutamate analogues.

被引：14

作者：

Baker, SR ^{[1
]}

Hancox, TC ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期

关键词：

amino acids; bicyclic aliphatic compounds; cyclisation;

D O I：

10.1016/S0040-4039(98)02411-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel [2.2.2]bicyclooctane analogue of glutamic acid was synthesised using a modification of the Corey-Link amino acid synthesis. A related [3.1.1]bicycloheptane was prepared by cyclising a symmetrical 4,4-disubstituted cyclohexanone. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：781 / 784

页数：4

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