The expression of vesicular glutamate transporters defines two classes of excitatory synapse

被引：1028

作者：

Fremeau, RT

Troyer, MD

Pahner, I

Nygaard, GO

Tran, CH

Reimer, RJ

Bellocchio, EE

Fortin, D

Storm-Mathisen, J

Edwards, RH

机构：

[1] Univ Calif San Francisco, Sch Med, Dept Neurol, Grad Program Neurosci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Med, Dept Neurol, Grad Program Cell Biol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Sch Med, Dept Neurol, Grad Program Biomed Sci, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Sch Med, Dept Physiol, Grad Program Biomed Sci, San Francisco, CA 94143 USA

[5] Univ Calif San Francisco, Sch Med, Dept Physiol, Grad Program Neurosci, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Sch Med, Dept Physiol, Grad Program Cell Biol, San Francisco, CA 94143 USA

[7] Univ Oslo, IMBA, Dept Anat, N-0317 Oslo, Norway

来源：

NEURON | 2001年 / 31卷 / 02期

关键词：

D O I：

10.1016/S0896-6273(01)00344-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse.

引用

页码：247 / 260

页数：14

共 53 条

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