Chemistry of substituted quinolinones. III. Synthesis and reactions of some novel 3-pyrazolyl-2-quinolinones

被引：21

作者：

Abass, M ^{[1
]}

Othman, ES ^{[1
]}

机构：

[1] Ain Shams Univ, Fac Educ, Dept Chem, Cairo 11711, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2001年 / 31卷 / 21期

关键词：

D O I：

10.1081/SCC-100106047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of 4-hydroxy-1-methyl-3-(5-oxo-4,5-dihydro-1H-3-pyrazolyl)-1,2-dihydro-2-quinolinone (3) and its hydrazono-, aminomethylidene- and arylidene derivatives has been achieved. The synthesis of fused heterocyclic polynuclear systems containing quinolinone moiety is also described. Quinolinones are an important class of heterocyclic therapeutic agents. Many 4-hydroxy-1,2-dihydro-2-quinolinones have a wide spectrum of pharmacological applications. For example, different quinolinones. revealed anti-tumor,(l) anti-HSV,(2) anti-convulsion,(3) anti-oxidation and anti-inflammatory activity(4) and bactericidal, fungicidal and molluscicidal activity.(5) Also, some pyrazoloquinolinones. showed potent biological activity.(6)

引用

页码：3361 / 3376

页数：16

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