PDE-5 inhibitor, Vardenafil, increases circulating progenitor cells in humans

被引：47

作者：

Foresta, C

Lana, A

Cabrelle, A

Ferigo, M

Caretta, N

Garolla, A

Palù, G

Ferlin, A

机构：

[1] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Ctr Male Gamete Cryopreservat, I-35121 Padua, Italy

[2] Univ Padua, Dept Clin & Expt Med, Padua, Italy

[3] Univ Padua, Dept Histol Microbiol & Med Biotechnol, Sect Microbiol & Virol, Padua, Italy

来源：

INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH | 2005年 / 17卷 / 04期

关键词：

endothelial progenitor cells; oral vasoactive agents;

D O I：

10.1038/sj.ijir.3901325

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Bone marrow-derived endothelial progenitor cells (EPCs) originate from haematopoietic stem cells in bone marrow and migrate into the peripheral circulation to promote endothelial repair and neovascularization. The number of circulating progenitor cells is reduced in patients with cardiovascular risk factor. The aim of our study was to determine the number of these cells in healthy patients and to evaluate the effect of Vardenfil, a phosphodiesterases-5 (PDE-5) inhibitor, in the number of circulating EPCs. In our study, we found a significant increase in the number of these cells after the drug administration.

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收藏

页码：377 / 380

页数：4

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