The role of STAT3 in tumor-mediated immune suppression

被引：61

作者：

Ferguson, Sherise D. ^{[1
]}

Srinivasan, Visish M. ^{[1
]}

Heimberger, Amy B. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurosurg, Houston, TX 77030 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2015年 / 123卷 / 03期

基金：

美国国家卫生研究院;

关键词：

STAT3; Glioblastoma; Immune suppression; REGULATORY T-CELLS; TRANSCRIPTION; 3; PATHWAY; MALIGNANT GLIOMA-CELLS; SIGNAL TRANSDUCERS; PHOSPHORYLATED STAT3; GASTRIC-CANCER; IN-VITRO; GLIOBLASTOMA; EXPRESSION; ACTIVATION;

D O I：

10.1007/s11060-015-1731-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The role of tumor-induced immune modulation in cancer progression is currently a focus of investigation. The signal transducer and activator of transcription 3 (STAT3) is an established molecular hub of immunosuppression, and its signaling pathways are classically overactivated within malignancies. This article will review STAT3 operational mechanisms within the immune system and the tumor microenvironment, with a focus on therapeutic strategies that may impact outcomes for patients with cancer.

引用

页码：385 / 394

页数：10

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