Expression of inducible nitric oxide-synthase in the vestibular system of hydropic guinea pigs

被引：26

作者：

Hess, A

Bloch, W

Su, JP

Stennert, E

Addicks, K

Michel, O

机构：

[1] Univ Cologne, Klin & Poliklin Hals Nasen & Ohrenheilkunde, Dept Otorhinolaryngol, D-50924 Cologne, Germany

[2] Univ Cologne, Dept Anat, D-50924 Cologne, Germany

[3] Guangyxi Med Univ, Dept Otolaryngol, Nanning 530021, Guangxi, Peoples R China

来源：

NEUROSCIENCE LETTERS | 1999年 / 264卷 / 1-3期

关键词：

endolymphatic hydrops; nitric oxide; NO-synthase II; vestibular dysfunction;

D O I：

10.1016/S0304-3940(99)00195-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunohistochemical investigations of the guinea pig vestibular system, using a specific antibody to the inducible isoform of NO-synthase (iNOS/NOS II), have been performed 3 weeks after surgical closure of the right endolymphatic duct (n = 7). Endolymphatic hydrops (ELH) of the right temporal bone became evident by excavation of the Reissner's membrane in all seven animals. Those animals revealed iNOS-expression in ganglion cells, in the wall of blood vessels and in nerve fibers of the right vestibular system, while the corresponding left temporal bones and temporal bones of non-operated controls (n = 6) as well as of sham-operated animals (n = 3) did not show any iNOS-positive structures. iNOS-generated NO could be involved in the pathophysiology of vestibular dysfunction in Meniere's disease. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：145 / 148

页数：4

共 19 条

[1] NO synthase-II is transiently expressed in embryonic mouse olfactory receptor neurons [J].