Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection

被引:57
作者
Fournel, I. [1 ]
Tiv, M. [1 ]
Soulias, M. [1 ]
Hua, C. [1 ]
Astruc, K. [1 ]
Glele, L. S. Aho [1 ]
机构
[1] Hop Bocage, Hosp Hyg & Epidemiol Unit, F-21079 Dijon, France
关键词
WOUND-INFECTION; PEROPERATIVE ANTIBIOTICS; ABDOMINAL OPERATIONS; SUBCUTANEOUS TISSUE; PREVALENCE SURVEY; IRRIGATION; APPENDECTOMY; EFFICACY; SEPSIS; LAVAGE;
D O I
10.1002/bjs.7212
中图分类号
R61 [外科手术学];
学科分类号
摘要
Background: The effectiveness of intraoperative povidone-iodine (PVI) application in the reduction of surgical-site infection (SSI) remains controversial. This meta-analysis was performed to assess the effect of intraoperative PVI application compared with no antiseptic solution (saline or nothing) on the SSI rate. Methods: The meta-analysis included randomized controlled trials that compared intraoperative PVI lavage with no PVI in patients undergoing surgery with SSI as the primary outcome. A fixed-effects or random-effects model was used as appropriate, and heterogeneity was assessed by the Cochran Q and the I-2 value. Results: Twenty-four randomized controlled trials totalling 5004 patients (2465 patients with PVI and 2539 patients without) were included: 15 in the main analysis and nine in the sensitivity analysis. The rate of SSI was 8.0 per cent in the PVI group and 13.4 per cent in the control group. Intraoperative PVI application significantly decreased the SSI rate (relative risk 0.58, 95 per cent confidence interval 0.40 to 0.83; P = 0.003) and consistent results were observed in subgroup analyses according to the method of PVI administration, its timing and the type of surgery. Conclusion: The meta-analysis results suggested that the use of intraoperative PVI reduced rates of SSI.
引用
收藏
页码:1603 / 1613
页数:11
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