Synthesis and biological activity of novel macrocyclic antifungals: Acylated conjugates of the ornithine moiety of the lipopeptidolactone FR901469

被引：12

作者：

Barrett, D

Tanaka, A

Harada, K

Ohki, H

Watabe, E

Maki, K

Ikeda, F

机构：

[1] Fujisawa Pharmaceut Co Ltd, Med Chem Res Labs, Yodogawa Ku, Osaka 5328514, Japan

[2] Fujisawa Pharmaceut Co Ltd, Med Biol Res Labs, Yodogawa Ku, Osaka 5328514, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)00705-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of acylated analogues of the novel macrocyclic lipopeptidolactone FR901469 has been prepared and evaluated for antifungal and hemolytic activity. Several analogues displayed markedly reduced hemolytic potential and comparable protective effects to the natural product in a mouse model of candidiasis. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：479 / 482

页数：4

共 11 条

[1] OPPORTUNISTIC MYCOSES IN THE IMMUNOCOMPROMISED HOST - EXPERIENCE AT A CANCER CENTER AND REVIEW [J].