Adipokines in inflammation and metabolic disease

被引：3215

作者：

Ouchi, Noriyuki ^{[2
]}

Parker, Jennifer L. ^{[1
]}

Lugus, Jesse J. ^{[1
]}

Walsh, Kenneth ^{[1
]}

机构：

[1] Boston Univ, Med Ctr, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[2] Nagoya Univ, Dept Mol Cardiol, Grad Sch Med, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 02期

关键词：

NECROSIS-FACTOR-ALPHA; INDUCED INSULIN-RESISTANCE; ACTIVATED PROTEIN-KINASE; RETINOL-BINDING-PROTEIN; ADIPOSE-TISSUE INFLAMMATION; C-REACTIVE PROTEIN; ADIPONECTIN STIMULATES ANGIOGENESIS; VASCULAR ENDOTHELIAL-CELLS; MORBIDLY OBESE SUBJECTS; FATTY-ACID OXIDATION;

D O I：

10.1038/nri2921

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.

引用

页码：85 / 97

页数：13

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